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Gene Gradients Reveal Directed Structural Connectivity Across Species

2026-05-06

Abstract excerpt

Diffusion MRI (dMRI) tractography is widely used to estimate structural connectivity (SC) between brain regions in vivo , but it cannot determine the direction of white matter pathways. Here, we introduce a structure-function computational model that combines dMRI-derived SC, gene co-expression gradients, and functional activity data to infer structural directionality. Our model accurately predicts ground truth d...

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Literature Corpus work
3c02b895-9827-5601-a20c-7d8b23ae32d7
DOI
10.64898/2026.05.05.723068
Open publication

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Gene Gradients Reveal Directed Structural Connectivity Across SpeciesDOI 10.64898/2026.05.05.723068
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