Article

Precision Grounding: Augmenting Large Language Models with Evidence-Based Databases for Trustworthy Genetic Variant Summarization

2025-06-10

Abstract excerpt

<h4>Backgrounds</h4> Accurate interpretation of genetic variants is critical for precision medicine. While large language models (LLMs) show promise for summarization, they are prone to hallucinations. In this study, we thus propose a novel approach named “precision grounding” that augments LLMs with a query tool that integrated evidence-based, variant-specific information to improve summarization accuracy. <h4>Me...

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Literature Corpus work: 3b304c3d-43f1-5a3b-b024-44b509ee2bcb
DOI: 10.1101/2025.06.09.25329279

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