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Article

Precision Grounding: augmenting large language models with evidence-based databases for trustworthy genetic variant summarization.

International journal of medical informatics - 1 Jul 2026

Du Xinsong, Nagy Anna, Oates Michael F, Wang Yifei, Wang Xinyi, Plasek Joseph M, Aronson Samuel J, Lebo Matthew S, Zhou Li

Abstract excerpt

PURPOSE: To propose a novel method that augments LLMs with evidence-based, variant-specific information to improve summarization accuracy and support clinical decision making. METHODS: We proposed Precision Grounding which uses a query tool that integrates domain expert-selected resources and allows users to query relevant factual information using identifiers in databases. In our case, which is genetic variant...

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PMID: 41950627
DOI: 10.1016/j.ijmedinf.2026.106424
PMCID: PMC13222032

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GPT

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