Article

MTSplice predicts effects of genetic variants on tissue-specific splicing

2020-06-08

Abstract excerpt

Tissue-specific splicing of exons plays an important role in determining tissue identity. However, computational tools predicting tissue-specific effects of variants on splicing are lacking. To address this issue, we developed MTSplice (Multi-tissue Splicing), a neural network which quantitatively predicts effects of human genetic variants on splicing of cassette exons in 56 tissues. MTSplice combines the state-of...

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Literature Corpus work: 397b25f9-c79d-5adf-801e-f1b61a6c1ea2
DOI: 10.1101/2020.06.07.138453

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