Differential importance of MSP4 and MSP5 for infection of red blood cells between human infecting malaria parasites

Abstract excerpt

Plasmodium species malaria parasites require invasion and replication within red blood cells to cause disease. Merozoite surface proteins (MSPs) are proposed to play a role in attachment of merozoites to RBCs and have long been considered as potential vaccine targets, but their functions during invasion are largely unknown. We applied targeted gene editing to investigate MSP4 and 5 function in P. falciparum , whi...

Topics

Open a Topic to create a Post that cites this publication.

• Amino Acid Sequence
• Base Sequence
• Genetic Variation
• Malaria Research and Control
• Molecular Sequence Data
• Mosquito-borne diseases and control
• Polymorphism, Restriction Fragment Length
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

38d0c377-3b16-51df-883e-39dd217403c7

DOI

10.1101/2025.08.28.672823