Article

Andrographolide exerts anti-respiratory syncytial virus activity by up-regulating heme oxygenase-1 independent of interferon responses in human airway epithelial cells

2022-08-19

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>Respiratory syncytial virus (RSV), the leading cause of mortality and morbidity in children under the age of five, is still lacking in safe and effective vaccines and antiviral agents for clinical use. Andrographolide exerts antiviral functions against a variety of viruses, but whether (and how) it exerts antiviral effects on RSV remains unclear.<bold>Methods an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 374deff4-8410-50b9-9765-012275d03f9d
DOI: 10.21203/rs.3.rs-1951880/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Andrographolide exerts anti-respiratory syncytial virus activity by up-regulating heme oxygenase-1 independent of interferon responses in human airway epithelial cellsDOI 10.21203/rs.3.rs-1951880/v1Read

Traditional Chinese medicine andrographolide sulfonate alleviates airway inflammation by supressing TRL3-TRIF in mice post respiratory syncytial virus infectionSemantic proximity Read

Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery.Semantic proximity Read

Antiviral and anti-inflammatory effects of Tabamide A derivative, TA25, against human rhinovirus and multiple zoonotic viruses in vitro and in silicoSemantic proximity Read

Respiratory Syncytial Virus Infection Induces Airway Hyperresponsiveness Through miR-34b/c-5p/CXCL10 AxisSemantic proximity Read

Antiviral drug synergy and mutational signatures in different epithelial cell models of RSV and hPIV infectionSemantic proximity Read

Antiviral activity of the non-steroidal anti-inflammatory drug indomethacin against Respiratory Syncytial VirusSemantic proximity Read

Antiviral and anti-inflammatory effects of Tabamide A derivative, TA25, against human rhinovirus and multiple zoonotic viruses in vitro and in silicoSemantic proximity Read

Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial VirusSemantic proximity Read

Arctiin Suppresses H9N2 Avian Influenza Virus-Mediated Inflammation Via Activation of Nrf2/HO-1 SignalingSemantic proximity Read

Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World HantavirusesSemantic proximity Read

Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivitySemantic proximity Read

Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infectionSemantic proximity Read