Article

ASSESSING THE RELATIONSHIP BETWEEN MONOALLELIC <i>PARK2</i> MUTATIONS AND PARKINSON’S RISK

2020-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Biallelic PARK2 (Parkin) mutations cause autosomal recessive Parkinson’s (PD); however, the role of monoallelic PARK2 mutations as a risk factor for PD remains unclear. We investigated the role of single heterozygous PARK2 mutations in three large independent case-control cohorts totalling 10,858 PD cases and 8,328 controls. Overall, after exclusion of biallelic carriers, single PARK2 mutations w...

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Literature Corpus work: 373814a4-8ca3-586b-a2fe-05b640ebb512
DOI: 10.1101/2020.06.26.20138172

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