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Genetic basis of dynamic brain states reveals cellular and disease associations

2026-06-12

Abstract excerpt

Dynamic resting-state fMRI captures the time-varying patterns of brain activity that are obscured by static approaches. Hidden Markov Models (HMMs) characterise these dynamics as recurring whole-brain states and quantify their fractional occupancy (FO), the proportion of time spent in each state, yet the biological basis of inter-individual variation in FO remains unclear. Using data from 52,335 White UK Biobank p...

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Literature Corpus work
36c49993-a0bf-51aa-aa37-1e76fbe443e6
DOI
10.64898/2026.06.10.26355409
Open publication

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