Article

Tracing the origin of Finnish gelsolin amyloidosis using haplotype sharing trees

2026-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Finnish gelsolin amyloidosis (AGel amyloidosis) is an autosomal dominant systemic amyloidosis caused by GSN c.640G>A p.D187N (rs121909715) founder variant. The disease was first described in 1969, and it was hypothesized that the Finnish patients share a common ancestor dating back to the 14th century. The link between two Finnish regions with high AGel incidence (Kanta-Häme and Kymenlaakso) has...

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Literature Corpus work: 34cf9c16-5951-56c1-972b-031057868887
DOI: 10.64898/2026.02.11.705340

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