Article

Targeting LINC00152 activates cAMP/Ca <sup>2+</sup> /ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer

2023-11-05

Abstract excerpt

Tamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER+) breast cancer, constituting around 75% of all cases. However, emergence of resistance is common, necessitating the identification of novel therapeutic targets. Here, we demonstrated that long-noncoding RNA LINC00152 confers tamoxifen resistance via blocking tamoxifen-induced ferroptosis, an iro...

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Literature Corpus work: 33fc0934-d0e1-52db-887e-defac624c83a
DOI: 10.1101/2023.11.05.565697

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