Article

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

2023-12-13

Abstract excerpt

Embryogenesis is a vulnerable time. Mutations in developmental cells can result in the wide dissemination of cells predisposed to disease within mature organs. We characterised the evolutionary history of four synchronous renal tumours from a 14-year-old girl, timing their shared origin to a multipotent embryonic cell committed to the right kidney, around 4 weeks post-conception. Their shared MTOR mutation, absen...

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Literature Corpus work: 3362cbd8-f82b-5964-aae0-c6b561e8315e
DOI: 10.1101/2023.12.12.570785

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