Article

Cerebrospinal fluid flow and clearance driven by lateral ventricle volume oscillations

2025-10-21

Abstract excerpt

In the human brain, substance clearance is intimately connected to the cerebrospinal fluid (CSF) and its flow. CSF extends from the lateral ventricles (LVs) to the parenchyma’s perivascular spaces. Macroscopic undulating CSF flow is present during both wakefulness and sleep and can be experimentally induced. However, the mechanisms generating this flow and its contribution to brain clearance remain unclear. Using...

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Literature Corpus work: 32e76f3b-8605-56d0-a936-ca9de16fad46
DOI: 10.1101/2025.10.20.683529

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