Article

CYP2D6 Genotyping for Personalized Therapy of Tamoxifen in Indonesian Women with ER+ Breast Cancer

2022-01-05

Abstract excerpt

<title>Abstract</title> <p>PurposeTamoxifen, common adjuvant therapy prescribed in estrogen receptor positive (ER+) breast cancer, is metabolized by CYP2D6 enzyme into endoxifen. The phenotypes of <italic>CYP2D6</italic>, a highly polymorphic gene, vary from ultrarapid (UM), normal (NM), intermediate (IM), and poor metabolizers (PM). Studies showed that reduced <italic>CYP2D6</italic> activity in IMs and PMs resu...

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Literature Corpus work: 2e0a33c9-9311-5adb-b4ba-d5cc1a6a0fec
DOI: 10.21203/rs.3.rs-1037721/v1

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