Article

Pharmacogenetics and Pharmacokinetics of Tamoxifen in a Zimbabwean breast cancer cohort

2023-04-06

Abstract excerpt

Tamoxifen is the most used hormonal therapy for estrogen receptor positive breast cancer. CYP2D6 is the main enzyme in the metabolic pathway of tamoxifen to endoxifen. Variations in endoxifen plasma concentrations are associated with CYP2D6 polymorphisms. This study aimed to determine the association between the CYP2D6 polymorphisms and endoxifen plasma concentrations in a cohort of Zimbabwean breast cancer patien...

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Literature Corpus work: 03a9aded-5f13-529c-a9b1-00328871371c
DOI: 10.22541/au.168081129.93760392/v1

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