Article

Intratumoral Heterogeneity of Ki67 Proliferation Index Outperforms Conventional Prognostic Factors in Hormone Receptor-Positive Breast Cancer

2023-08-31

Abstract excerpt

<h4>Background: </h4> Immunohistochemistry (IHC) for ER, PR, HER2, and Ki67 is used in breast cancer (BC) pathology to assess tumor properties and predict patient outcomes and therapy responses. Visual scoring of the IHC biomarkers by pathologists, apart from reproducibility issues, does not sufficiently account for the intratumoral heterogeneity (ITH), often a subvisual feature within the tumor tissue. It has bee...

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Literature Corpus work: 2da312d3-72a9-5279-9eaa-8b622dbd9e1b
DOI: 10.21203/rs.3.rs-3302114/v1

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