Article

Targeting Prohibitin 2-Hsp70A1A complex during Plasmodium falciparum invasion of erythrocytes as a novel approach towards vaccine candidacy

2023-10-06

Abstract excerpt

<title>Abstract</title> Malaria parasite invade human erythrocytes in the merozoite stage that contribute towards the development of disease pathology. Invasion is mediated by multiple interactions between merozoite ligands and erythrocyte receptors. Here, we report a novel interaction of Plasmodium prohibitin ‘PfPHB2’ with human Hsp70A1A that plays a crucial role in mediating host-parasite interaction during...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cf049ec-3962-5679-b77f-448e431cc617
DOI: 10.21203/rs.3.rs-3375700/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Prohibitin 2-Hsp70A1A complex during Plasmodium falciparum invasion of erythrocytes as a novel approach towards vaccine candidacyDOI 10.21203/rs.3.rs-3375700/v1Read

Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasiteSemantic proximity Read

Multi-protein chimeric antigens, a novel combined approach for efficiently targeting and blocking the blood stage of Plasmodium falciparumSemantic proximity Read

An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodiesSemantic proximity Read

Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite InvasionSemantic proximity Read

Comprehensive characterization of Plasmodium vivax antigens using a high-density peptide arraySemantic proximity Read

Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasionSemantic proximity Read

Naturally-acquired and Vaccine-induced Human Monoclonal Antibodies to Plasmodium vivax Duffy Binding Protein Inhibit Invasion of Plasmodium knowlesi (PvDBPOR) Transgenic ParasitesSemantic proximity Read

Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidatesSemantic proximity Read

Evidence That the Erythrocyte Invasion Ligand PfRh2 is a Target of Protective Immunity against Plasmodium falciparum MalariaSemantic proximity Read

Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasitesSemantic proximity Read

Targeting Plasmodium falciparum Invasion via Antibodies Against Merozoite Surface Enolase That Binds to Band 3 of Human Red Blood CellsSemantic proximity Read

Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription FactorSemantic proximity Read