Article

Empirically derived phenotypes can reduce diagnostic heterogeneity

2026-08-04

Abstract excerpt

<p>Diagnostic heterogeneity is a longstanding challenge for the classification of mental illness because people who receive the same diagnosis can differ markedly in their symptom presentations as well as in the mechanisms underlying those symptoms. High heterogeneity undermines both the clinical utility of diagnostic labels and the scientific accuracy of research that treats disorders as coherent constructs. In t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c941eb8-df06-50ae-9c4b-ccd15e0391da
DOI: 10.31234/osf.io/8wtqx_v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Empirically derived phenotypes can reduce diagnostic heterogeneityDOI 10.31234/osf.io/8wtqx_v2Read

Empirically derived phenotypes can reduce diagnostic heterogeneitySemantic proximity Read

Translating the Hierarchical Taxonomy of Psychopathology (HiTOP) from Potential to Practice: Ten Research QuestionsSemantic proximity Read

The Hierarchical Taxonomy of Psychopathology (HiTOP) in psychiatric practice and research.Semantic proximity Read

Comparison of algorithm-based versus single-item diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohortsSemantic proximity Read

Meta-analysis of structural evidence for the Hierarchical Taxonomy of Psychopathology (HiTOP) model.Semantic proximity Read

Rethinking mental disorder diagnosis: Data-driven psychological dimensions, not categories, as a framework for mental health research, treatment, and trainingSemantic proximity Read

Psychometric Properties of Hierarchical Psychiatric Symptoms on the General PopulationSemantic proximity Read

Validation and Heritability of the Hierarchical Taxonomy of PsychopathologySemantic proximity Read

Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework.Semantic proximity Read

Validity and Heritability of the Hierarchical Taxonomy of PsychopathologySemantic proximity Read

Understanding DSM: A Critical Commentary on Descriptive Diagnosis, Disease Validity, and Clinical UtilitySemantic proximity Read

Integrating clinical staging and phenomenological psychopathology to add depth, nuance, and utility to clinical phenotyping: a heuristic challenge.Semantic proximity Read