Article

Evaluating potential drug targets through human loss-of-function genetic variation

2019-01-28

Abstract excerpt

Human genetics has informed the clinical development of new drugs, and is beginning to influence the selection of new drug targets. Large-scale DNA sequencing studies have created a catalogue of naturally occurring genetic variants predicted to cause loss of function in human genes, which in principle should provide powerful in vivo models of human genetic “knockouts” to complement model organism knockout studies...

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Literature Corpus work: 2c5d4324-1778-51a3-bdc2-4f3bd9ec1d08
DOI: 10.1101/530881

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