Article

Generalization and extinction of learned fear alter primary sensory input to the brain

2026-02-27

Abstract excerpt

Neuroplasticity in sensory systems permits the brain to refine sensory discrimination between threat-predictive and neutral stimuli, but dysfunctional sensory plasticity might underlie maladaptive fear generalization. Using an odor-cued fear conditioning paradigm designed to induce broad fear generalization in a mouse model, we found that odor-evoked synaptic output from olfactory nerve into the brain’s olfactory...

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Literature Corpus work: 2c257e7a-fd25-5fad-afe8-56b504cad2e1
DOI: 10.64898/2026.02.25.708099

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