citrOgen: a synthesis-free polysaccharide and protein antigen-presentation to antibody-induction platform

Abstract excerpt

Existing technologies employed to generate antibodies against bacterial polysaccharides and proteins rely on the availability of purified or synthetic antigens. Here we present a genetics-based platform that utilises Citrobacter rodentium (CR), an enteric mouse pathogen, to both produce and present complex heterologous polysaccharides and protein antigen complexes during natural infection. As proof of concept, we...

Topics

Open a Topic to create a Post that cites this publication.

• Bacterial Infections and Vaccines
• Bacteriophages and microbial interactions
• Escherichia coli research studies
• Monoclonal and Polyclonal Antibodies Research
• Pneumonia and Respiratory Infections
• Probiotics and Fermented Foods
• Protein purification and stability
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

2b9fee65-085e-539d-83c9-468a41d00b71

DOI

10.1101/2025.03.14.643335