Article

Phase 1, dose-escalation trial of the safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies (DMAb) in healthy adults

2025-03-12

Abstract excerpt

<title>Abstract</title> <p>Local intramuscular administration of synthetic plasmid DNA (pDNA) encoding monoclonal antibodies (mAb) represents an alternative approach to recombinant protein technology. In this Phase 1, dose escalation study (NCT05293249), we administered a pDNA cocktail encoding AZD5396 and AZD8076, modified versions of the SARS-CoV-2 neutralizing mAb cocktail Evusheld™, by CELLECTRA™ in vivo elec...

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Literature Corpus work: 2a5533dd-3eea-508e-a695-d788932945e1
DOI: 10.21203/rs.3.rs-6066550/v1

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Phase 1, dose-escalation trial of the safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies (DMAb) in healthy adultsDOI 10.21203/rs.3.rs-6066550/v1Read

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