Profiling the effects of rifaximin on the healthy human colonic microbiota using a chemostat model

Abstract excerpt

Rifaximin is a low solubility antibiotic with activity against a wide range of bacterial pathogens. It accumulates in the intestine and is suitable for prolonged use. Three chemostat models (A, B and C) were used to investigate the effects of three rifaximin formulations (α, β and κ, respectively) on the gut microbiome. Bacterial populations were monitored by bacterial culture and 16S rRNA gene amplicon (16S) sequ...

Topics

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• Algorithms
• Anti-Bacterial Agents
• Bacteria
• Clostridium difficile and Clostridium perfringens research
• Drug Resistance, Bacterial
• Gastrointestinal Microbiome
• Gut microbiota and health
• Mutation

Identifiers and source

Literature Corpus work

2a36b547-03dc-564d-8ad1-7ef59d56adf8

DOI

10.1101/828269