Article

Design, development, and evaluation of gene therapeutics specific to KSHV-associated diseases

2025-02-19

Abstract excerpt

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi’s sarcoma (KS) and two human lymphoproliferative diseases: primary effusion lymphoma and AIDS-related multicentric Castleman’s disease. KSHV-encoded latency-associated nuclear antigen (LANA) is expressed in KSHV-infected cancer cells and is responsible for maintaining viral genomes in infected cells. Thus, LANA is an attractive target...

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Literature Corpus work: 2a2c3162-dcfb-5fce-a5f8-7d512cc5e784
DOI: 10.1101/2025.02.19.639178

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