Article

ChatGPT vs DeepSeek: A Comparative Study of Diagnostic Accuracy and Clinical Reasoning in Rare and Complex Diseases

2025-08-28

Abstract excerpt

Diagnostic errors in rare and complex diseases contribute significantly to morbidity and mortality. The ability of large language models (LLMs) to enhance diagnostic performance in such cases remains uncertain. This study compares the diagnostic accuracy, clinical reasoning quality, and inference efficiency of three ChatGPT variants (o3-mini, o3-mini-high, o1) and DeepSeek-R1 using 30 English-language case reports...

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Literature Corpus work: 29fb06cf-6bd8-53f6-b9d2-55a4e99e3b1c
DOI: 10.1101/2025.08.28.25331796

Open publication

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