Fishing with Two Lines: A Hybrid Approach to Spatial Transcriptomic Discovery

Abstract excerpt

Spatial transcriptomics faces a trade-off between the number of genes assayed and depth of per-gene sensitivity. We developed a ‘dual chemistry’ method that combines the high sensitivity of a 10X Genomics Xenium V1 custom panel (up to 480 genes) with the broad coverage of the Prime 5K panel (5001 genes) on a single tissue section. This involved co-hybridizing Prime and V1 probes and sequentially running the V1 and...

Topics

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• Drug Design
• Gene Expression Profiling
• HIV Protease Inhibitors
• Liver
• Lymphoma, B-Cell
• Phenotype
• Technology
• Transcriptome

Identifiers and source

Literature Corpus work

29f1faf7-b1d1-5169-b30c-68c9eeeb64d6

DOI

10.64898/2026.01.07.698201