Article

A Four-Dimensional Computational Model of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Measurement of Subtle Blood-Brain Barrier Leakage

2020-10-09

Abstract excerpt

Dynamic contrast-enhanced MRI (DCE-MRI) is increasingly used to quantify and map the spatial distribution of blood-brain barrier (BBB) leakage in neurodegenerative disease, including cerebral small vessel disease and dementia. However, the subtle nature of leakage and resulting small signal changes make quantification challenging. While simplified one-dimensional simulations have probed the impact of noise, scanne...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 298b7d03-89c5-581e-ab88-d47e521ac50e
DOI: 10.20944/preprints202010.0200.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Four-Dimensional Computational Model of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Measurement of Subtle Blood-Brain Barrier LeakageDOI 10.20944/preprints202010.0200.v1Read

caliPER: A software for blood-free parametri c P a t l ak mapp i ng using PE T/M R I input functionSemantic proximity Read

Deep-Learning-Based Accelerated and Noise-Suppressed Estimation (DANSE) of quantitative Gradient Recalled Echo (qGRE) MRI metrics associated with Human Brain Neuronal Structure and Hemodynamic PropertiesSemantic proximity Read

Submillimeter diffusion MRI using an in-plane segmented 3D multi-slab acquisition and denoiser-regularized reconstructionSemantic proximity Read

Biophysical Mechanisms of Microscopic Diffusional Kurtosis in diffusion MRISemantic proximity Read

Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosisSemantic proximity Read

Quantitative Characterization of Tumoural Leakage Phenomena Using Dynamic Susceptibility Contrast Perfusion Imaging Semantic proximity Read

Simulation-Based Inference at the Theoretical Limit: Fast, Accurate Microstructural MRI with Minimal diffusion MRI DataSemantic proximity Read

The impact of human brain geometry on the transport of an intrathecal tracerSemantic proximity Read

Hierarchical Bayesian Modelling Improves Microstructural Parameter Mapping in Diffusion and Exchange MRI DataSemantic proximity Read

Increased brain coverage and efficiency when measuring current-induced magnetic fields by use of simultaneous multi-slice echo-planar MRISemantic proximity Read

Physics-Informed Neural Network for Mapping Vascular and Tissue Dynamics Using Laser Speckle Contrast ImagingSemantic proximity Read

Non-invasive full quantification of dynamic [11C]PBR28 PET imaging with ASTRASemantic proximity Read