Article

Targeting Hedgehog pathway and DNA methyltransferases suppress the phenotype of uterine leiomyosarcoma cells

2020-05-27

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Uterine leiomyosarcoma (LMS) is an aggressive tumor with poor prognosis, high rates of recurrence and metastasis. Several studies have shown an essential role of Hedgehog (HH) signaling in tumor development. The role of HH pathway in LMS is still unclear. <bold>Methods: </bold>Uterine smooth muscle (USTM) and LMS cells lines were used to evaluate the mRNA and pr...

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Literature Corpus work: 27a35528-69d3-513d-828f-cc6cf6b86157
DOI: 10.21203/rs.3.rs-27677/v1

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