Article

CFTR Complex Alleles in Individuals with Cystic Fibrosis Showing Limited Response to Elexacaftor/Tezacaftor/Ivacaftor (ETI) Triple Modulator Therapy

2026-06-04

Abstract excerpt

<title>Abstract</title> <p>Background In many people with cystic fibrosis (CF, pwCF), genetic diagnosis often detects only common CFTR variants. Complex alleles—multiple variants on the same allele—frequently remain undetected, yet can influence CFTR function, response to modulators such as elexacaftor/tezacaftor/ivacaftor (ETI), and disease progression. Understanding CF’s genetic diversity is essential for advan...

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Literature Corpus work: 26c72e5c-1b4a-5a27-9740-4f7e5b2502d3
DOI: 10.21203/rs.3.rs-9310406/v1

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