Article

Genomic and proteomic evidence for hormonal and metabolic foundations of polycystic ovary syndrome

2024-04-19

Abstract excerpt

Polycystic ovary syndrome (PCOS) and its underlying features remain poorly understood. In this genetic and proteomic study, we expand the number of genetic loci from 19 to 29, and identify 31 associated plasma proteins. Many risk-increasing loci were associated with later age at menopause, underscoring the reproductive longevity related to a larger functional ovarian reserve. Hormonal regulation in the aetiology o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 265f0f65-9ead-5069-a673-8eb071a27d7e
DOI: 10.1101/2024.04.18.24306020

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic and proteomic evidence for hormonal and metabolic foundations of polycystic ovary syndromeDOI 10.1101/2024.04.18.24306020Read

Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome.Semantic proximity Read

Pathomechanisms of polycystic ovary syndrome Multidimensional approachesSemantic proximity Read

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary SyndromeSemantic proximity Read

POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Genetics of polycystic ovary syndrome (PCOS).Semantic proximity Read

Polycystic ovary syndrome--phenotypes and diagnosis.Semantic proximity Read

Proteomics and polycystic ovary syndromeSemantic proximity Read

Characteristics of polycystic ovary syndrome throughout lifeSemantic proximity Read

Polycystic ovary syndrome (PCOS): international collaboration to translate evidence and guide future research.Semantic proximity Read

Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian SyndromeSemantic proximity Read

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology.Semantic proximity Read

Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and ClassificationSemantic proximity Read

Polycystic Ovarian Syndrome: A Complex Disease with a Genetics ApproachSemantic proximity Read