Article

Daraxonrasib (RMC-6236) is an effective targeted therapy for <i>RAS</i> -mutant neuroblastoma

2026-02-20

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Relapsed or refractory (R/R) high-risk (HR) NB tumors continue to exhibit poor outcomes despite intensive and protractive multimodal therapy. Activating mutations in the RAS- mitogen-activated protein kinase (MAPK) pathway are frequently observed in R/R HRNB. The early promise of ALK inhibitors to treat ALK -mutant NB underscores the abil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 264d3969-d4a6-54e7-9a20-e6a5806a4999
DOI: 10.64898/2026.02.19.706849

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Daraxonrasib (RMC-6236) is an effective targeted therapy for <i>RAS</i> -mutant neuroblastomaDOI 10.64898/2026.02.19.706849Read

Efficacy of RMC-6236 (Daraxonrasib) and novel combination strategies targeting resistance in RAS pathway-driven neuroblastomaSemantic proximity Read

MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastomaSemantic proximity Read

Targeting RAS in neuroblastoma: Is it possible?Semantic proximity Read

Limited antitumor activity of combined BET and MEK inhibition in neuroblastomaSemantic proximity Read

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastomaSemantic proximity Read

Cell Survival Signaling in NeuroblastomaSemantic proximity Read

Therapeutic targets for neuroblastomas.Semantic proximity Read

Aurora B kinase is a potent and selective target in MYCN-driven neuroblastomaSemantic proximity Read

EGFR signaling defines Mcl-1 survival dependency in neuroblastomaSemantic proximity Read

Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in NeuroblastomaSemantic proximity Read

NRAS-Mutated Rhabdomyosarcoma Cells Are Vulnerable to Mitochondrial Apoptosis Induced by Coinhibition of MEK and PI3Kα.Semantic proximity Read

NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma.Semantic proximity Read