Article

Multiplexed Quantification of First-Trimester Serum Biomarkers in Healthy Pregnancy

2025-07-24

Abstract excerpt

The maternal circulating proteome reflects critical physiological adaptations during pregnancy, yet standardized reference profiles for early gestation are lacking. In this pro-spective study, we employed targeted liquid chromatography-multiple reaction monitor-ing-mass spectrometry (LC-MRM-MS) with stable isotope-labeled (SIS) standards to char-acterize the serum proteome of 83 women with uncomplicated singleton...

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Literature Corpus work: 26420650-11fd-5af3-b794-1ec22f8a42b5
DOI: 10.20944/preprints202507.1975.v1

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