Gly-tRF Enhances LCSCs-Like Cells Stemness and Promotes EMT of HCC Cells via Targeting NDFIP2 and Activating AKT Signaling Pathway.

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The existence of liver cancer stem cells (LCSCs) and the occurrence of epithelial-mesenchymal transition (EMT) are generally considered to be the primary causes for migration and metastasis of Hepatocellular carcinoma (HCC). Accumulating evidences demonstrate that tRFs and tiRNAs, are an emerging category of regulatory RNA molecules derived from transfer RNA (tR...

Topics

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• Extracellular vesicles in disease
• Gene Transfer Techniques
• Genetic Therapy
• MicroRNAs
• Mutation
• Neoplasms
• RNA, Messenger
• RNA Processing, Post-Transcriptional

Identifiers and source

Literature Corpus work

25adcb5f-120c-5bc9-a4cf-71d15745ac46

DOI

10.21203/rs.3.rs-198357/v1