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<i>In silico </i>analysis of multiple targets (HER2 receptor and DNA) inhibition by natural isoquinoline derivatives for breast cancer treatment

2022-01-01

Abstract excerpt

Breast cancer is one of the major challenges for women's health worldwide. Approximately 15-30% of breast cancer aggressiveness is caused by over-reactivity of the HER2 receptor enzyme. Hence, the inhibition of HER2 has become a promising approach for the treatment of human breast cancer. In this in silico study, the binding interactions of five natural isoquinoline derivatives with the HER2 enzyme (PDB Id 3PPO) a...

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Literature Corpus work
25595f8c-6df8-5bec-8f9d-241a69abc3bd
DOI
10.1504/ijcbdd.2022.128239
Open publication

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