Article

Characterization of the molecular mechanism of the tissue-specific and developmentally regulated alternative splicing of SCN9A Exon 5

2015-01-01

Abstract excerpt

The voltage-gated sodium channel Nav 1.7, encoded by SCN9A gene, is expressed in dorsal root ganglia (DRG) and in sympathetic ganglia and it is considered to be one of the major player in the regulation of pain perception. The linkage to several human pain disorders confirms its pivotal role in pain pathway. The gene contains an exon 5 pair, 5N and 5A, that are mutually exclusive spliced. These exons encode part o...

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Literature Corpus work: 24a57151-8b2a-5a02-891e-8d3e577a771c
DOI: 10.21954/ou.ro.0000ef98

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