Article

Individualized Antisense Oligonucleotides for SCN2A Related Developmental Epileptic Encephalopathy

2025-10-18

Abstract excerpt

<title>Abstract</title> <p>SCN2A variants are one of the most common genetic causes of intractable epilepsy in children, particularly in developmental and epileptic encephalopathies (DEEs) which can present with uncontrolled seizures at birth, accounting for 1-2% of all epileptic encephalopathies. There is significant genotype-phenotype heterogeneity in SCN2A-related disorders (SRD) which include neurologic sympt...

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Literature Corpus work: 2309e238-8b24-52aa-949d-c369b052cbd5
DOI: 10.21203/rs.3.rs-7841195/v1

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