Article

Antagonistic pathogen-mediated selection favours the maintenance of innate immune gene polymorphism in a widespread wild ungulate

2018-10-31

Abstract excerpt

Toll-like Receptors (TLR) play a central role in recognition and host frontline defence against a wide range of pathogens. A number of recent studies have shown that TLR genes ( Tlrs ) often exhibit a large polymorphism in natural populations. Yet, there is little knowledge on how this polymorphism is maintained and how it influences disease susceptibility in the wild. In a previous work, we showed that some Tlr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22f0d5ae-18ca-5600-9c95-694434b14353
DOI: 10.1101/458216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antagonistic pathogen-mediated selection favours the maintenance of innate immune gene polymorphism in a widespread wild ungulateDOI 10.1101/458216Read

Immunogenetic heterogeneity in a widespread ungulate: the European roe deer (Capreolus capreolus).Semantic proximity Read

Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak.Semantic proximity Read

Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions.Semantic proximity Read

Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.Semantic proximity Read

An overview of the lagomorph immune system and its genetic diversity.Semantic proximity Read

Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like ReceptorsSemantic proximity Read

Wildlife Trade and Genetic Basis of Disease Susceptibility: A ReviewSemantic proximity Read

Functional polymorphisms in Toll-like receptor genes for innate immunity in farm animals.Semantic proximity Read

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.Semantic proximity Read

Decomposing variation in immune response in a wild rodent populationSemantic proximity Read

Host specificity, pathogen exposure, and superinfections impact the distribution of Anaplasma phagocytophilum genotypes in ticks, roe deer, and livestock in a fragmented agricultural landscape.Semantic proximity Read

Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent.Semantic proximity Read