Article

p53 is not necessary for DUX4 pathology

2017-03-19

Abstract excerpt

<h4>Abstracts</h4> FSHD is a genetically dominant myopathy caused by mutations that cause expression of the normally silent DUX4 gene. This transcription factor has been shown to interfere with myogenesis when misexpressed at very low levels in myoblasts, and to cause cell death when overexpressed at high levels. A previous report using adeno-associated virus to deliver high levels of DUX4 to mouse skeletal musc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2188e80c-316b-5351-b447-701005cc8e9f
DOI: 10.1101/118315

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

p53 is not necessary for DUX4 pathologyDOI 10.1101/118315Read

p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.Semantic proximity Read

<i>DUX4</i>, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53‐dependent myopathy in vivoSemantic proximity Read

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.Semantic proximity Read

A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.Semantic proximity Read

Cellular and animal models for facioscapulohumeral muscular dystrophySemantic proximity Read

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.Semantic proximity Read

RNA Interference Inhibits DUX4-induced Muscle Toxicity In Vivo: Implications for a Targeted FSHD TherapySemantic proximity Read

Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severitySemantic proximity Read

Transgenic mouse models for investigating human <i>DUX4</i> expression during development and its roles in FSHD pathophysiologySemantic proximity Read

Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene.Semantic proximity Read

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies.Semantic proximity Read

DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesisSemantic proximity Read