Article

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signalling nanodomains

2024-10-03

Abstract excerpt

Large conductance calcium-activated potassium channels (BK channels) are unique in their ability to respond to two distinct physiological stimuli: intracellular Ca 2+ and membrane depolarization. In neurons, these channels are activated through a coordinated response to both signals; however, for BK channels to respond to physiological voltage changes, elevated concentrations of intracellular Ca 2+ (ranging from...

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Literature Corpus work: 1f481395-8960-5071-a007-b9f2dd84fe20
DOI: 10.1101/2024.10.02.616357

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