Back to search

Article

Integrin-based prognostic model predicts survival, immunotherapy response, and drug sensitivity in gastric cancer

2023-05-02

Abstract excerpt

Extracellular matrix (ECM) acts as a physical barrier to tumors, resulting in the lysis or delay of drug delivery. Integrins (ITGs) are essential for tumor cell-ECM interactions. Thus, we established a novel prognostic model to predict overall survival, immunotherapy benefits, and therapeutic agents in gastric cancer (GC) based on ITGs-related ECM landscape. Using the TCGA-STAD dataset, we studied the genetic and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1c865c9b-e5fd-576f-9d0c-fe381d61d610
DOI
10.1016/j.bmt.2023.04.002
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrin-based prognostic model predicts survival, immunotherapy response, and drug sensitivity in gastric cancerDOI 10.1016/j.bmt.2023.04.002
A Stromal-Immune Gene Signature for Precision Prognosis and Therapeutic Guidance in Gastric CancerSemantic proximity
Progressive and Prognostic Performance of an Extracellular Matrix-Receptor Interaction Signature in Gastric CancerSemantic proximity
Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric CancerSemantic proximity
Extracellular Matrix Characterization in Gastric Cancer Helps to Predict Prognosis and Chemotherapy ResponseSemantic proximity
An Integrated Analysis of The Prognosis And Immune Cell Infiltration of ITGB Superfamily Members In Gastric CancerSemantic proximity
Construction and verification of matrix stiffness-related prognostic model of gastric cancer based on single-cell analysis and in vitro experimentsSemantic proximity
Comprehensive Analysis of the Prognostic Value of ITGB Superfamily Members in Gastric Cancer Using Bioinformatics AnalysisSemantic proximity
Lung adenocarcinoma-specific three-integrin signature contributes to poor outcomes by metastasis and immune escape pathwaysSemantic proximity
ITGB1 as a prognostic biomarker correlated with immune suppression in gastric cancerSemantic proximity
ncRNAs-mediated high expression of ITGB1 correlates with poor prognosis and tumor immune infiltration in gastric cancerSemantic proximity
Immunogenomic characterization in gastric cancer identifies microenvironmental and immunotherapeutically relevant gene signatures.Semantic proximity
Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint BlockadeSemantic proximity
Select a neighboring publication to make it the new centre.