Article

The Role of Bone Marrow Microenvironment in Osteogenesis Imperfecta: Evidence from Single-Cell RNA Sequencing

2026-08-24

Abstract excerpt

INTRODUCTION: Osteogenesis imperfecta (OI) is a genetic disorder primarily due to mutations in collagen type I-encoding genes, resulting in fragile bones, frequent fractures, pain, and mobility issues. Disease severity and phenotype vary widely, even with the same mutation, suggesting the importance of other factors within the bone microenvironment that influence disease severity. To study the role of such factors...

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Literature Corpus work: 1bfce4cb-a785-592d-be89-ab45bf47b454
DOI: 10.64898/2026.08.21.26361022

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