Article

SARS-CoV-2 infection reduces the number of spermatogonial stem cells and dysregulates the transcriptional landscape of the human testis

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 coronavirus emerged in 2019, leading to the Coronavirus disease 2019 (COVID-19). Expression of viral entry factors such as ACE2 and TMPRSS2 is higher in the testis, particularly in Sertoli cells, Leydig cells, and spermatogonia. To understand COVID-19's impact on testicular cell populations and gene expression, we analyzed testicular tissue samples from 28 COVID-19 patients a...

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Literature Corpus work: 1bed6cbe-03f9-581f-91a5-5cb1181f4d2e
DOI: 10.21203/rs.3.rs-9371895/v1

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