Article

Hematogenous neuroinvasion and genotype-dependent transmission of influenza A H5N1 viruses in the cat host

2026-02-22

Abstract excerpt

The spillover of highly pathogenic avian influenza (HPAI) A H5N1 virus to mammalian hosts raises major concerns due to its pandemic potential. Cats are frequently affected mammals, often succumbing to systemic and neurological disease. Here, we characterized the pathogenesis and transmissibility of two H5N1 genotypes, B3.13 and D1.1, in cats. Infected cats exhibited high-level viremia and virus shedding in nasal,...

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Literature Corpus work: 1b558a96-b80e-5583-9c2a-561b896db9a8
DOI: 10.64898/2026.02.21.707182

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