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Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats.

Emerging microbes & infections - 1 Dec 2025

Chothe Shubhada K, Srinivas Surabhi, Misra Sougat, Nallipogu Noel Chandan, Gilbride Elizabeth, LaBella Lindsey, Mukherjee Swastidipa, Gauthier Christian H, Pecoraro Heidi L, Webb Brett T, Pipas James M, Ramasamy Santhamani, Kuchipudi Suresh V

Abstract excerpt

In April 2024, ten cats died in a rural South Dakota (SD) residence, showing respiratory and neurological symptoms. Necropsy and laboratory testing of two cats confirmed H5N1 clade 2.3.4.4b infection. The viral genome sequences are closely related to recent SD cattle H5N1 sequences. Cat H5N1 genomes had unique mutations, including T143A in haemagglutinin, known to affect infectivity and immune evasion, and two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39648950
DOI: 10.1080/22221751.2024.2440498
PMCID: PMC11654043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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