High-efficiency expression of a novel antimicrobial peptide I20 with superior bactericidal ability and biocompatibility in Pichia pastoris and its efficiency enhancement to aquaculture

Abstract excerpt

One of the major constraints on aquaculture is the susceptibility of farmed fish to diseases or slow growing. Antimicrobial peptide I20, as a novel feed additive, is used to cope with these limiting factors. In the current study, the Pichia pastoris expression system was used to produce I20 in large quantities, thereby reducing its application cost. In terms of molecular strategy, the I20 expression codon was opti...

Topics

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• Anti-Bacterial Agents
• Bacteriocins
• Escherichia coli
• Gram-Negative Bacteria
• Microbial Sensitivity Tests
• Mutation
• Pseudomonas aeruginosa
• Recombinant Fusion Proteins

Identifiers and source

Literature Corpus work

1b237f90-2c22-571b-bb15-527e0063a13d

DOI

10.1016/j.aquaculture.2023.740149