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Subcallosal Cingulate Deep Brain Stimulation and Heart Rate Variability in Treatment-Resistant Depression: Evidence for Person-Specific Autonomic Phenotypes

2026-04-08

Abstract excerpt

<p>Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an established intervention for treatment-resistant depression (TRD) that modulates white-matter tracts within the central autonomic network (CAN). In eight patients with TRD, SCC DBS produced robust antidepressant effects but no group-level change in heart-rate variability (HRV), a marker of vagal flexibility. However, patients whose mood and HRV cova...

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Literature Corpus work
1afb0bd8-c7e3-5326-b183-56a191070290
DOI
10.31234/osf.io/rxzmd_v4
Open publication

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