Article

Bacteria-induced expression of the pig-derived protegrin-1 transgene specifically in the respiratory tract of mice enhances resistance to airway bacterial infection

2020-04-29

Abstract excerpt

<title>Abstract</title> <p>Background About 70% of all antibiotics produced in the world are used in the farm animal industry. The massive usage of antibiotics during farm animal production has caused rapid development of antibiotic resistance in bacteria, which poses a serious risk to human and livestock health when treating bacterial infections. Protegrin-1 (PG-1) is a potent antimicrobial peptide (AMP), initia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1abcdeb4-9615-58c9-84e2-7ab88fde3230
DOI: 10.21203/rs.3.rs-23320/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bacteria-induced expression of the pig-derived protegrin-1 transgene specifically in the respiratory tract of mice enhances resistance to airway bacterial infectionDOI 10.21203/rs.3.rs-23320/v1Read

Defining the genetic relationship of protegrin-related sequences and the in vivo expression of protegrins.Semantic proximity Read

The pig as a medical model for acquired respiratory diseases and dysfunctions: An immunological perspectiveSemantic proximity Read

Harnessing antimicrobial peptide genes to expedite disease-resistant enhancement in aquaculture: Transgenesis and genome editingSemantic proximity Read

Single-blinded Study Highlighting the Differences between the Small Intestines of Neonatal and Weaned PigletsSemantic proximity Read

Generation of Marker-Free pbd-2 Knock-in Pigs Using the CRISPR/Cas9 and Cre/loxP Systems.Semantic proximity Read

Transgenic strategies to increase disease resistance in livestock.Semantic proximity Read

Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection.Semantic proximity Read

Transgenic milk containing recombinant human lactoferrin modulates the intestinal flora in piglets<sup>1</sup>This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal’s usual peer review process.Semantic proximity Read

mRNA-Based Vaccines are Highly Immunogenic and Confer Protection in the Gnotobiotic Pig Model of Human Rotavirus DiarrheaSemantic proximity Read

Ceftiofur Treatment of Sows Results in Long-Term Alterations in the Nasal Microbiota of the Offspring That Can Be Ameliorated by Inoculation of Nasal ColonizersSemantic proximity Read

Transgenic mice expressing a soluble form of porcine nectin-1/herpesvirus entry mediator C as a model for pseudorabies-resistant livestockSemantic proximity Read

Transgenic animals resistant to infectious diseases.Semantic proximity Read