Article

An Enhanced Variant-Aware Deep Learning Model for Individual Gene Expression Prediction

2025-11-14

Abstract excerpt

Accurate prediction of gene expression from individual whole-genome sequences is critical for understanding disease mechanisms and advancing precision medicine. Current methods, however, struggle with individual-specific genetic variations and integrating detailed sequence context. To address this, we introduce GenomicVariExpress (GVE), a novel deep learning model that leverages a pre-trained sequence encoder and...

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Literature Corpus work: 19591b9d-b99c-50e0-aa9a-8b2c3c1789b1
DOI: 10.1101/2025.11.12.688070

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