Article

Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

2021-11-08

Abstract excerpt

The precise molecular mechanisms behind life-threatening lung abnormalities during severe SARS-CoV-2 infections are still unclear. To address this challenge, we performed whole transcriptome sequencing of lung autopsies from 31 patients suffering from severe COVID-19 related complications and 10 uninfected controls. Using a metatranscriptome analysis of lung tissue samples we identified the existence of two distin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 191ed297-bfe1-5275-acb5-abe055eb325d
DOI: 10.1101/2021.11.08.467705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortalityDOI 10.1101/2021.11.08.467705Read

Single‐cell RNA sequencing reveals characteristics of myeloid cells in post-acute sequelae of SARS-CoV-2 patients with persistent respiratory symptomsSemantic proximity Read

Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2Semantic proximity Read

Inflammasome activation and pulmonary viral loads define two distinct clinical outcomes in COVID-19Semantic proximity Read

Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolutionSemantic proximity Read

Viral genomic, metagenomic and human transcriptomic characterization and prediction of the clinical forms of COVID-19Semantic proximity Read

Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomesSemantic proximity Read

Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsSemantic proximity Read

Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired TranscriptionSemantic proximity Read

Comparative transcriptomic analyses of peripheral blood mononuclear cells of patients with non-pneumonia and severe pneumonia at 1 year-Long-COVID-19Semantic proximity Read

Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samplesSemantic proximity Read

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19Semantic proximity Read

Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsSemantic proximity Read