Article

An ELISA DYRK1A non-radioactive kinase assay suitable for the characterization of inhibitors

2017-03-24

Abstract excerpt

The DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) gene encodes a proline-directed Ser/Thr kinase. Elevated expression and/or altered distribution of the kinase have been implicated in the neurological impairments associated with Down syndrome (DS) and Alzheimer’s disease (AD). Consequently, DYRK1A inhibition has been of significant interest as a potential strategy for therapeutic intervent...

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Literature Corpus work: 16e6c256-1579-5d0b-9225-add0937abce9
DOI: 10.12688/f1000research.10582.2

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