Article

Elimination of BRAF p.V600E under selective pressure of BRAF-targeted therapy and expansion of a PIK3CA p.E542K clone in a patient with recurrent malignant glomus tumor

2025-08-05

Abstract excerpt

<title>Abstract</title> <p>Glomus tumors are rare mesenchymal tumors that resemble modified smooth muscle cells of the normal glomus body. <italic>BRAF</italic> p.V600E has previously been detected in glomus tumors and is associated with more aggressive clinical behavior. Here, we report a case of a patient with a malignant <italic>BRAF</italic>-mutant glomus tumor that initially responded to BRAF targeted therap...

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Literature Corpus work: 15ae2d65-90f4-5f6e-a289-40203e695830
DOI: 10.21203/rs.3.rs-7041059/v1

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